Moslehi N, Vafa M, Rahimi-Foroushani A, Golestan B (2012) Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women. Talari HR, Zakizade M, Soleimani A, Bahmani F, Ghaderi A, Mirhosseini N, Eslahi M, Babadi M, Mansournia MA, Asemi Z (2019) Effects of magnesium supplementation on carotid intima-media thickness and metabolic profiles in diabetic haemodialysis patients: a randomised, double-blind, placebo-controlled trial. Clin Pharmacol : advances and applications 12:159–169.
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Sobhani AR, Farshidi H, Azarkish F, Eslami M, Eftekhar E, Keshavarz M, Soltani N (2020) Magnesium sulfate improves some risk factors for atherosclerosis in patients suffering from one or two coronary artery diseases: a double-blind clinical trial study. Arch Biochem Biophys 458(1):48–56ĭibaba DT, Xun P, He K (2014) Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review. Mazur A, Maier JA, Rock E, Gueux E, Nowacki W, Rayssiguier Y (2007) Magnesium and the inflammatory response: potential physiopathological implications. Nielsen FH (2018) Magnesium deficiency and increased inflammation: current perspectives.
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BMC Med 14(1):1–13ĭe Borst MH, de Baaij JH (2020) Low serum magnesium as a risk factor for peripheral artery disease in chronic kidney disease: an open verdict. Nutr Clin Pract 23(2):142–151įang X, Wang K, Han D, He X, Wei J, Zhao L, Imam MU, Ping Z, Li Y, Xu Y (2016) Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose–response meta-analysis of prospective cohort studies. Nutrients 7(9):8199–8226Ĭhampagne CM (2008) Magnesium in hypertension, cardiovascular disease, metabolic syndrome, and other conditions: a review. Gröber U, Schmidt J, Kisters K (2015) Magnesium in prevention and therapy. The findings of the present systematic review and meta-analysis did not support the notion that oral magnesium supplementation could have favorable effects on CRP, IL-6, and TNF-α in the adult population. In addition, based on dose–response assessment, no significant non-linear association was found between magnesium supplementation dosage or duration on serum CRP and IL-6 concentrations. A total of 18 studies with 927 participants fulfilled the eligibility criteria and included in this meta-analysis. We also performed a subgroup analysis to identify probable sources of heterogeneity. The Cochrane Collaboration tool was used to assess the quality of each study. The major databases including PubMed, Web of Science, Embase, and Google Scholar were searched for relevant publications until December 14, 2020, using appropriate keywords. Our analysis suggests that CGA programmes linking geriatric evaluation with strong long-term management are effective for improving survival and function in older persons.This is a comprehensive systematic review and dose–response meta-analysis evaluating the effects of oral magnesium supplementation on inflammatory biomarkers including C-reactive protein (CRP), interleukin‐6 (IL‐6), and tumor necrosis factor-alpha (TNF‐α) among adults. Covariate analysis showed that programmes with control over medical recommendations and extended ambulatory follow-up were more likely to be effective. Combined odds ratio (95% confidence interval) of living at home at follow-up was 1♶8 (1♱7-2 41) for geriatric evaluation and management units, 1♴9 (1♱2-1♹8) for hospital-home assessment services, and 1♲0 (1♰5-1♳7) for home assessment services. We calculated combined odds ratios of important outcomes by pooling data from individual trials with multivariate logistic regression. Published data were supplemented with reanalysed data provided by the original investigators. We did a meta-analysis on 28 controlled trials comprising 4959 subjects allocated to one of five CGA types and 4912 controls.
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There is disagreement on the usefulness of comprehensive geriatric assessment (CGA) due to conflicting results from individual trials.